????????????????MHRA?
?MHRA??????????3??????�Drug Safety Update newsletter�?�Public Assessment Report�??????????????venous thromboembolic?VTE??????????????????????????????????
Drug Safety Update: Volume 2 Issue 11, June 2009(MHRA)
http://www.mhra.gov.uk/Publications/Safetyguidance/DrugSafetyUpdate/CON049070
MHRA Public Assessment Report: The risk of venous thromboembolism associated with antipsychotics - June 2009 (MHRA PDF:636KB??37???)
?VTE?????????????DVT:deep vein thrombosis? ?????????????????PE:pulmonary embolism??????????
?MHRA???1963?7???2008?6?????????????????????????????????????????????????303??DVT?PE??????????????????????????????????????VTE???????11????????????????
?�Public Assessment Report�?????303??????DVT?107??PE?146?????50???????????????????????????271????????????????????????????186??????69??????????????????35????????????????33???????????
????�Public Assessment Report�??????????????????????????????????retrospective???????????????????????????????????????????VTE?????????????????????
??????????????????????????????????????????????????
?????????MHRA?????????????????????????????EU???????????????????????????????????????
- ?????????VTE???????????????????
- ????????????????????????????????????????????
- ????????????????VTE???????????????????????????????????
?MHRA?????????????????????????????????????????????????????????????????????VTE????????????????
?EU?????????????????????????????????????????VTE????????????????????????????????????????????????????????????????
??????????????????
?http://www.novartis.co.jp/product/clo/pi/pi_clo.pdf
???Antipsychotic drugs?MHRA?
???
MHRA Drug Safety Update: Antipsychotics and risk of venous thromboembolic events?National electronic Library for Medicine 2009.6.4?
????????????????????
?http://mmh.banyu.co.jp/mmhe2j/sec03/ch036/ch036b.html
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