????????????????
????????????????????????????????????????JAMA ??????????700???????????????????????Gardasil??????????????????????????
Postlicensure Safety Surveillance for Quadrivalent Human Papillomavirus Recombinant Vaccine
?(JAMA. 2009;302(7):750-757.)
?http://jama.ama-assn.org/cgi/content/abstract/302/7/750
FULLTEXT?????????????????????????????????
The Risks and Benefits of HPV Vaccination
??JAMA. 2009;302(7):795-796.?
?http://jama.ama-assn.org/cgi/content/full/302/7/795
FDA???????????????????????????
Gardasil Vaccine Safety Information from FDA And CDC on the Safety of Gardasil Vaccine?FDA?2009.8.20?
?http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/VaccineSafety/ucm179549.htm
?????????????????????????????VAERS?Vaccine Adverse Event Reporting System?????2006?6???2008?12???????12,424??100,000????53.9???????????????????
???12,424????93.8???????????????6.2?????772????????????????32??????????????????????66%????/??11%?????10%????????????1%??????12%??????????????
| 100,000? ???? ???? |
??????? |
|---|---|
| 8.2 | ??(syncope) |
| 7.5 | ?????local site reactions? |
| 6.8 | ????dizziness? |
| 5.0 | ????nausea? |
| 4.1 | ???Headache? |
| 3.1 | ??????hypersensitivity reactions? |
| 2.6 | ??????urticaria? |
| 0.2 | ????????????VTE??venous thromboembolic events????????? autoimmune disorders????????????Guillain-Barre syndrome? |
| 0.1 | ?????????anaphylaxis?????death? |
| 0.04 | ???????transverse myelitis?????pancreatitis? |
??????????????????????????????????????????????????????????????????????????????VTE?(???????????????)??????????????????
?????????580???????????????TGA????????????????????
Human papillomavirus vaccine (GARDASIL)???TGA?
?http://www.tga.health.gov.au/alerts/medicines/gardasil.htm
?TGA??2009?8?10????1394?????????????????????????????????????????????????????
????????????????????Cervarix?GSK??????????????????????????????????????????????????????????????????
???????????????????????????????????
?????????http://www.orangeclover.org/
?????TOPICS
???2007.02.04?????????????????????????
????????????????????????????NVIC?National Vaccine Information Center??http://www.nvic.org/?????????????????????????????
Preventing Gardasil Vaccine Injuries & Deaths
?NVIC Vaccine News 2009.07.14?
http://www.nvic.org/NVIC-Vaccine-News/July-2009/Preventing-Gardasil-Vaccine-Injuries-Deaths.aspx
??????????????????????????????
投稿者 by ???????? — 2009年8月22日(土)17:59
?????CDC?????????????11?12?????????????????????????????????????????????????
Should your daughter get Gardasil, the vaccine against HPV?
??CNN?2009.8.13??????
?http://www.cnn.com/2009/HEALTH/08/13/hpv.vaccine.gardasil/
???????????????????????????????????2008?9??????????????????????????????????????1112?????????11?12??????????????????48.5?????????????
Human Papillomavirus Vaccine Recommendations and Agreement with Mandated Human Papillomavirus Vaccination for 11-to-12-Year-Old Girls: a Statewide Survey of Texas Physicians
??Cancer Epidemiol Biomarkers Prev 2009;18(8):2325–32?
?http://cebp.aacrjournals.org/cgi/content/abstract/18/8/2325
CNN???????CDC????????????2007??????13-17??25?????????????????????????11-12??15????????????
???????????????????????????????????????????????????11-12??????????????????????????????????????????????????????????????????????????????????????????????????????????????????
???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
????????????????????????????????????????????????????????????????????????????
投稿者 by ???????? — 2009年8月24日(月)00:14