?????R?????????

????????????????????????????????????????????????PPI??????????????????????????????????

?CMAJ ??????????28?????????????????????????????????????????????????

A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
???CMAJ Early release 2009.1.28?
??http://www.cmaj.ca/cgi/rapidpdf/cmaj.082001v1.pdf

???????????????????????????????3??????????????????????66???????13636?????????90?????????????????????????????????40????????2?????????????????????????????

????????????????????????????????????????????PPI?pantoprazole????????????????????????2?19?????????????2?19??????????????????????????????????????????

???????????????????????????????????????????????????????????????????????????????????pantoprazole????????????????????

????????????????FDA???26??Early Communication????????????????????????????????????????????????????

Early Communication about an Ongoing Safety Review of clopidogrel bisulfate (marketed as Plavix)(FDA 2009.1.26)
http://www.fda.gov/Safety/MedWatch/SafetyInformation/
SafetyAlertsforHumanMedicalProducts/ucm092066.htm

???????????????????????????????????????CMAJ ????????????????????????????????????????????????????????????????????????????????

?????
American College of Cardiology (ACC)/American College of Gastroenterology (ACG)/American Heart Association (AHA) Joint Comment on Studies Regarding Possible Interaction of Clopidogrel and Proton Pump Inhibitors
?American Heart Association News Release 2008.11.11?
?http://americanheart.mediaroom.com/index.php?s=43&item=611

???
Some anti-acid meds may reduce Plavix efficacy
?CTV.Ca 2009.1.28?
http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20090128
/plavix_study_090128/20090128?hub=Health
Some heartburn drugs raise risk of 2nd heart attack: study
?CBC.Ca?2009.1.28?
http://www.cbc.ca/health/story/2009/01/28/heart-attack-ppi.html
Plavix Plus Heartburn Drugs May Hike Heart Risk
?HealthDay 2009.1.28?
http://www.healthday.com/Article.asp?AID=623549