???????????????
??????????????????????Institute for Safe Medication Practices?ISMP??http://www.ismp.org/??23??2008???????(1??3?)?�FDA adverse event reports�???????????????�Quarter Watch: 2008 Quarter 1�?????????
Quarter Watch: 2008 Quarter?ISMP 2008.10.23?
??http://www.ismp.org/QuarterWatch/2008Q1.pdf
??????????2008????????FDA??104,823????????????????????????????20,745????????????????38????????????4,824???????????2.6??????2004??????????????????
| ???? | ???? | ||||
|---|---|---|---|---|---|
| 1 | ?????? | 1001 | 1 | ?????? | 185 |
| 2 | ???? | 779 | 2 | ??????? | 163 |
| 3 | ?????? | 631 | 3 | ????????? | 160 |
| 4 | ????????? | 582 | 4 | ??????????????????????? | 156 |
| 5 | ???????? | 463 | 5 | ?????? | 131 |
| 6 | ??????? | 401 | 6 | ???? | 115 |
| 7 | ??????? | 297 | 7 | ??????? | 114 |
| 8 | Pregabalin | 280 | 8 | ???? | 111 |
| 9 | ????????? | 273 | 9 | ???????????????? | 111 |
| 10 | ?????? | 272 | 10 | ???? | 102 |
????????????????????????????1464??7.1%???????????????????medication errors?????????
??????????disruptions of the heart rhythm???2658?????????????????suicide and self injury ??1932??????????????drug dependence and withdrawal???1814?????????????????????Angioedema?????103??Pregabalin58????????52?????????Suicide/Self Injury???????226????????89?????????????????? 87??????Hemorrhage????????170????????161??????88?????????????????
?????????????????????????????????????????????????????????????
?????1001?????????????50?????????????????????????????????17??bupropion????????????44??????????????????????10?????????????837????????????????????????15??????52????????????????2006?????????3325?????????????112???
?FDA?????????????????????????????????????????????????????????????????????????????????????????????????FDA??????????????????????????
????????????????????????????????????????????????????????????????????????????????????????????????????????????????
????????????????????????(???????????????????????
?????TOPICS 2008.05.22??????????????????????
???Smoking Cessation Drug Linked to 1,001 New Serious Adverse Events
??????Medpage TODAY 2008.10.22?
????http://www.medpagetoday.com/PrimaryCare/Smoking/11428