?????R?????????

?20?????????????????????????????????????????????????????????????David G. Bailey????????????????????????????????????????????????????????????????????????????????????????????????????????????????????

New reasons to avoid grapefruit and other juices when taking certain drugs?EureK Alert! 2008.8.19?
??http://www.eurekalert.org/pub_releases/2008-08/acs-nrt072308.php

????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
????Clin Pharmacol Ther. 2002 Jan;71(1):11-20?
?http://www.ncbi.nlm.nih.gov/pubmed/11823753

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??http://microsomes.hp.infoseek.co.jp/fruit_juice.htm

Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides.
??Clin Pharmacol Ther. 2005 Mar;77(3):170-7?
??http://www.ncbi.nlm.nih.gov/pubmed/15735611

???????????????????????????????1?2?OAYP1A2??????????????????????????????????????????????????????????????????????????????????????????Tailinolol?????????????????????????????????????????????????????????????

Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.
(Clin Pharmacol Ther.2007 Apr;81(4):495-502. Epub 2007 Feb 14?
?http://www.ncbi.nlm.nih.gov/pubmed/17301733

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???
More Juices Found to Affect Drugs’ Effectiveness: Study
???HealthDay 2008.8.19)
??http://www.healthday.com/Article.asp?AID=618569
New Reasons To Avoid Grapefruit And Other Juices When Taking Certain Drugs?Science Daily2008.8.20)
??http://www.sciencedaily.com/releases/2008/08/080819160050.htm
Juices ‘could render drugs useless’(AP 2008.8.20)
??http://ukpress.google.com/article/ALeqM5i–SUpd6zhMfwab7rCtUNhF6qgkg