???????????????
??FDA?7??????????????????????????????????????????????????????????musculoskeletal??????????????????????????
Information on Bisphosphonates?FDA 2008.1.7?
??http://www.fda.gov/cder/drug/infopage/bisphosphonates/default.htm
?Information for Healthcare Professionals
Bisphosphonates (marketed as Actonel, Actonel+Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid, and Zometa)
??http://www.fda.gov/cder/drug/InfoSheets/HCP/bisphosphonatesHCP.htm??
???????????????????????????????????????????????????????????????????FDA????????????????????????????????????????????????
?FDA?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
????????????????????????????????????????????????????????????????????????1?1????????????????????????????????
Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention.
?J Musculoskelet Neuronal Interact 2007; 7(2):144-148?
????PubMed?PMID:17627083?
????http://www.ismni.org/jmni/pdf/28/06BOCK.pdf
???Bisphosphonate Use Can Cause Severe Musculoskeletal Pain, FDA Says
?????Health-System Pharmacy News 2008.1.7?
?http://www.ashp.org/s_ashp/article_news.asp?CID=167&DID=2024&id=23741
FDA Reminds Physicians of Link Between Bisphosphonates and Musculoskeletal Pain??MedpageTODAY 2008.1.7?
?http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/7872
U.S. warns of severe pain with osteoporosis drugs
?????????2007.1.7?
?http://www.reuters.com/article/healthNews/idUSN0740958620080107
Actonel, Fosamax, other Osteoporosis Drugs Draw FDA Pain Warning
????????NEWSInferno.com 2007.1.7?
?http://www.newsinferno.com/archives/2326
1?8??12:20??