???????????????????????????
??FDA?17??????nursing mothers?????????????????????????????????????????????????????????????????????????????????????????
FDA Warning on Codeine Use by Nursing Mothers
?May Increase Chance of Serious Side Effects in Infants
??FDA?2007.8.17?
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm108968.htm
Use of Codeine Products in Nursing Mothers?FDA 2007.8.17?
http://www.fda.gov/Drugs/DrugSafety/
PostmarketDrugSafetyInformationforPatientsandProviders/ucm118108.htm
????????????????(?????? ????????)Vol.5 No.18??????????
??http://www.nihs.go.jp/dig/sireport/weekly5/18070906.pdf
?????????80??????CYP3A4?????????????????-?-????????????????????????????10??CYP2D6??????????????????????????????????
??????????????????????CYP2D6??CYP2D6??????????????????????????ultrarapid metabolisum????????????????????????????2004??NEJM ?????????????????????????20??80????????????????????
Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
????NEJM 2004;351: 2827-2831?
???http://content.nejm.org/cgi/content/abstract/351/27/2827
???????????????????(???From Ph.?? 2005?6?18?)
?http://www.officemiks.com/yakujien/fromph2/nikki.cgi?act=browse&nmb=236&year=05
????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
Safety of codeine during breastfeeding: Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine. ?Canadian family physician 2007?53: 33-35?
??http://www.cfp.ca/cgi/content/full/53/1/33???NEJM ?????????
?????????????????????????????????????????????????????????????????????????????????????????????FDA??????????????????????????????????????????????????????????????????????????????????????????????????????????????
Information for Healthcare Professionals Use of Codeine Products in Nursing Mothers?FDA 2007.8.17?
http://www.fda.gov/Drugs/DrugSafety/
PostmarketDrugSafetyInformationforPatientsandProviders/ucm124889.htm
?FDA????????????????????????????????????????????1??????????????????????????????????OTC??????????????????????????????????????????????????
???????????????????????????
????????81?????????????
???FDA warns nursing moms of pain drug risk
???? -Side effect of codeine can cause overdose in breast-feeding infants
?????MSNBC 2007.8.17?AP???
???????http://www.msnbc.msn.com/id/20319327/
???Codeine can turn toxic in nursing mothers: doctor?CTV Ca 2006.5.11?
8?18??18:30???9?10???????2009?12?2???????