???????????
????????????????? Avadia(????Rosiglitazone??????)??????????????????????????????43??????64???????????????21??New England Journal of Medicine????????????????????????????
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
??????N Engl J Med ??????2007.5.21?
???http://content.nejm.org/cgi/content/full/NEJMoa072761
???????42?????28,000???????????????????????????????????????????????????????????????????????????????????????????????????????
??????????????Glaxo SmithKline????????????????????FDA????????????????????????????????????????????????????
FDA Issues Safety Alert on Avandia (FDA NEWS 2007.5.21)
??http://www.fda.gov/bbs/topics/NEWS/2007/NEW01636.html
?Information for Healthcare Professionals Rosiglitazone (marketed as Avandia)
??http://www.fda.gov/cder/drug/InfoSheets/HCP/rosiglitazoneHCP.htm
GlaxoSmithKline responds to NEJM article on Avandia
???Glaxo SmithKline 2007.5.21?
?http://www.gsk.com/ControllerServlet?appId=4&pageId=402&newsid=1038
Rosiglitazone????????????????????????????PPAR??????????????????????????????????????????????????????2005?FDA??????????????????muraglitazar (Pargluva) ?????????????????????????????
????????????????????????????Rosiglitazone????????????????????????????????????????????????????????Avandia??????????????????TAKEDA??????????????????????????
?????????????????????????PROactive????????????????????????????????????
?????????????????????2006.6.13?
???http://www.takeda.co.jp/press/06061301j.htm
?????????????????????????????????Public Citizen??22???Avandia????????2002???????????????FDA?????Avandia???????Actos??????????????????????????????????????????”Black-box”warnings??????????????????????????FDA?????????????
?FDA Knew of Avandia�s Dangers Nearly Five Years Ago, Memo Shows
??-Public Citizen Urges FDA to Act?Public Citizen 2007.5.22?
?????http://www.citizen.org/pressroom/release.cfm?ID=2442
??Letter Demonstrating that the FDA Knew About Avandia Dangers,
?? Urging Action?Public Citizen 2007.5.22?
?????http://www.citizen.org/publications/release.cfm?ID=7523
?????????FDA???????????????????????????????????????????????????????????????
??????????? ??????????????????????Vol.5 No.11
??????http://www.nihs.go.jp/dig/sireport/weekly5/11070531.pdf
?????Rosiglitazone and Cardiovascular Risk
???????N Engl J Med ??????2007.5.21?
??????http://content.nejm.org/cgi/content/full/NEJMe078099
?????TOPICS 2007.03.10????????????????
???Diabetes drug linked to heart attacks, death
??????MSNBC 2007.5.21 AP???
?????http://www.msnbc.msn.com/id/18783816/
????Meta-Analysis Links Rosiglitazone (Avandia) to Risk of Myocardial Infarction
??????medpage TODAY 2007.5.21?
?????http://www.medpagetoday.com/Endocrinology/Diabetes/tb/5701
????Rosiglitazone therapy linked to increased cardiovascular risks
???? in meta-analysis?Pharmacist.com 2007.5.21?
?????http://www.pharmacist.com/articles/h_ts_1460.cfm
????Advocacy group says FDA knew Avandia�s risk?MSNBC 2007.5.22 ???????
?????http://www.msnbc.msn.com/id/18807835/
????Doctor warned of Avandia risk in 2000?MSNBC 2007.5.24 ???????
?????http://www.msnbc.msn.com/id/18842687
5?26????6?4??????